LymphedemaV1, Main, Exploration, bibRecord, 000936

Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors.

Identifieur interne : 000936 ( Main/Exploration ); précédent : 000935; suivant : 000937

Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors.

Auteurs : Masahiro Shin [États-Unis] ; Ira Male [États-Unis] ; Timothy J. Beane [États-Unis] ; Jacques A. Villefranc [États-Unis] ; Fatma O. Kok [États-Unis] ; Lihua J. Zhu [États-Unis] ; Nathan D. Lawson [États-Unis]

Source :

Development (Cambridge, England) [ 1477-9129 ] ; 2016.

RBID : pubmed:27621059

Descripteurs français

English descriptors

KwdEn :
- Animals, Animals, Genetically Modified, Cells, Cultured, Extracellular Signal-Regulated MAP Kinases (genetics), Extracellular Signal-Regulated MAP Kinases (metabolism), Gene Expression Regulation, Developmental (genetics), Gene Expression Regulation, Developmental (physiology), Genotype, In Situ Hybridization, Lymphatic Vessels (cytology), Lymphatic Vessels (embryology), Lymphatic Vessels (metabolism), Mutation (genetics), Phosphorylation (genetics), Phosphorylation (physiology), Signal Transduction (genetics), Signal Transduction (physiology), Vascular Endothelial Growth Factor C (genetics), Vascular Endothelial Growth Factor C (metabolism), Vascular Endothelial Growth Factor Receptor-3 (genetics), Vascular Endothelial Growth Factor Receptor-3 (metabolism), Zebrafish (embryology), Zebrafish (metabolism), Zebrafish Proteins (genetics), Zebrafish Proteins (metabolism).
MESH :
- chemical , genetics : Extracellular Signal-Regulated MAP Kinases, Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor Receptor-3, Zebrafish Proteins.
- chemical , metabolism : Extracellular Signal-Regulated MAP Kinases, Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor Receptor-3, Zebrafish Proteins.
- cytology : Lymphatic Vessels.
- embryology : Lymphatic Vessels, Zebrafish.
- genetics : Gene Expression Regulation, Developmental, Mutation, Phosphorylation, Signal Transduction.
- metabolism : Lymphatic Vessels, Zebrafish.
- physiology : Gene Expression Regulation, Developmental, Phosphorylation, Signal Transduction.
- Animals, Animals, Genetically Modified, Cells, Cultured, Genotype, In Situ Hybridization.

Abstract

Vascular endothelial growth factor C (Vegfc) activates its receptor, Flt4, to induce lymphatic development. However, the signals that act downstream of Flt4 in this context in vivo remain unclear. To understand Flt4 signaling better, we generated zebrafish bearing a deletion in the Flt4 cytoplasmic domain that eliminates tyrosines Y1226 and 1227. Embryos bearing this deletion failed to initiate sprouting or differentiation of trunk lymphatic vessels and did not form a thoracic duct. Deletion of Y1226/7 prevented ERK phosphorylation in lymphatic progenitors, and ERK inhibition blocked trunk lymphatic sprouting and differentiation. Conversely, endothelial autonomous ERK activation rescued lymphatic sprouting and differentiation in flt4 mutants. Interestingly, embryos bearing the Y1226/7 deletion formed a functional facial lymphatic network enabling them to develop normally to adulthood. By contrast, flt4 null larvae displayed hypoplastic facial lymphatics and severe lymphedema. Thus, facial lymphatic vessels appear to be the first functional lymphatic network in the zebrafish, whereas the thoracic duct is initially dispensable for lymphatic function. Moreover, distinct signaling pathways downstream of Flt4 govern lymphatic morphogenesis and differentiation in different anatomical locations.

DOI: 10.1242/dev.137901
PubMed: 27621059

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors.</title>
<author><name sortKey="Shin, Masahiro" sort="Shin, Masahiro" uniqKey="Shin M" first="Masahiro" last="Shin">Masahiro Shin</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Male, Ira" sort="Male, Ira" uniqKey="Male I" first="Ira" last="Male">Ira Male</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beane, Timothy J" sort="Beane, Timothy J" uniqKey="Beane T" first="Timothy J" last="Beane">Timothy J. Beane</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Villefranc, Jacques A" sort="Villefranc, Jacques A" uniqKey="Villefranc J" first="Jacques A" last="Villefranc">Jacques A. Villefranc</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kok, Fatma O" sort="Kok, Fatma O" uniqKey="Kok F" first="Fatma O" last="Kok">Fatma O. Kok</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhu, Lihua J" sort="Zhu, Lihua J" uniqKey="Zhu L" first="Lihua J" last="Zhu">Lihua J. Zhu</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lawson, Nathan D" sort="Lawson, Nathan D" uniqKey="Lawson N" first="Nathan D" last="Lawson">Nathan D. Lawson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA nathan.lawson@umassmed.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27621059</idno>
<idno type="pmid">27621059</idno>
<idno type="doi">10.1242/dev.137901</idno>
<idno type="wicri:Area/PubMed/Corpus">000535</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000535</idno>
<idno type="wicri:Area/PubMed/Curation">000535</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000535</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000535</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000535</idno>
<idno type="wicri:Area/Ncbi/Merge">008793</idno>
<idno type="wicri:Area/Ncbi/Curation">008793</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">008793</idno>
<idno type="wicri:Area/Main/Merge">000937</idno>
<idno type="wicri:Area/Main/Curation">000936</idno>
<idno type="wicri:Area/Main/Exploration">000936</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors.</title>
<author><name sortKey="Shin, Masahiro" sort="Shin, Masahiro" uniqKey="Shin M" first="Masahiro" last="Shin">Masahiro Shin</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Male, Ira" sort="Male, Ira" uniqKey="Male I" first="Ira" last="Male">Ira Male</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beane, Timothy J" sort="Beane, Timothy J" uniqKey="Beane T" first="Timothy J" last="Beane">Timothy J. Beane</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Villefranc, Jacques A" sort="Villefranc, Jacques A" uniqKey="Villefranc J" first="Jacques A" last="Villefranc">Jacques A. Villefranc</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kok, Fatma O" sort="Kok, Fatma O" uniqKey="Kok F" first="Fatma O" last="Kok">Fatma O. Kok</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhu, Lihua J" sort="Zhu, Lihua J" uniqKey="Zhu L" first="Lihua J" last="Zhu">Lihua J. Zhu</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lawson, Nathan D" sort="Lawson, Nathan D" uniqKey="Lawson N" first="Nathan D" last="Lawson">Nathan D. Lawson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA nathan.lawson@umassmed.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Development (Cambridge, England)</title>
<idno type="eISSN">1477-9129</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Animals, Genetically Modified</term>
<term>Cells, Cultured</term>
<term>Extracellular Signal-Regulated MAP Kinases (genetics)</term>
<term>Extracellular Signal-Regulated MAP Kinases (metabolism)</term>
<term>Gene Expression Regulation, Developmental (genetics)</term>
<term>Gene Expression Regulation, Developmental (physiology)</term>
<term>Genotype</term>
<term>In Situ Hybridization</term>
<term>Lymphatic Vessels (cytology)</term>
<term>Lymphatic Vessels (embryology)</term>
<term>Lymphatic Vessels (metabolism)</term>
<term>Mutation (genetics)</term>
<term>Phosphorylation (genetics)</term>
<term>Phosphorylation (physiology)</term>
<term>Signal Transduction (genetics)</term>
<term>Signal Transduction (physiology)</term>
<term>Vascular Endothelial Growth Factor C (genetics)</term>
<term>Vascular Endothelial Growth Factor C (metabolism)</term>
<term>Vascular Endothelial Growth Factor Receptor-3 (genetics)</term>
<term>Vascular Endothelial Growth Factor Receptor-3 (metabolism)</term>
<term>Zebrafish (embryology)</term>
<term>Zebrafish (metabolism)</term>
<term>Zebrafish Proteins (genetics)</term>
<term>Zebrafish Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animal génétiquement modifié</term>
<term>Animaux</term>
<term>Cellules cultivées</term>
<term>Danio zébré (embryologie)</term>
<term>Danio zébré (métabolisme)</term>
<term>Extracellular Signal-Regulated MAP Kinases (génétique)</term>
<term>Extracellular Signal-Regulated MAP Kinases (métabolisme)</term>
<term>Facteur de croissance endothéliale vasculaire de type C (génétique)</term>
<term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term>
<term>Génotype</term>
<term>Hybridation in situ</term>
<term>Mutation (génétique)</term>
<term>Phosphorylation (génétique)</term>
<term>Phosphorylation (physiologie)</term>
<term>Protéines de poisson-zèbre (génétique)</term>
<term>Protéines de poisson-zèbre (métabolisme)</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire (génétique)</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme)</term>
<term>Régulation de l'expression des gènes au cours du développement (génétique)</term>
<term>Régulation de l'expression des gènes au cours du développement (physiologie)</term>
<term>Transduction du signal (génétique)</term>
<term>Transduction du signal (physiologie)</term>
<term>Vaisseaux lymphatiques (cytologie)</term>
<term>Vaisseaux lymphatiques (embryologie)</term>
<term>Vaisseaux lymphatiques (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Extracellular Signal-Regulated MAP Kinases</term>
<term>Vascular Endothelial Growth Factor C</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
<term>Zebrafish Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Extracellular Signal-Regulated MAP Kinases</term>
<term>Vascular Endothelial Growth Factor C</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
<term>Zebrafish Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Danio zébré</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic Vessels</term>
<term>Zebrafish</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Expression Regulation, Developmental</term>
<term>Mutation</term>
<term>Phosphorylation</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Extracellular Signal-Regulated MAP Kinases</term>
<term>Facteur de croissance endothéliale vasculaire de type C</term>
<term>Mutation</term>
<term>Phosphorylation</term>
<term>Protéines de poisson-zèbre</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphatic Vessels</term>
<term>Zebrafish</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Danio zébré</term>
<term>Extracellular Signal-Regulated MAP Kinases</term>
<term>Facteur de croissance endothéliale vasculaire de type C</term>
<term>Protéines de poisson-zèbre</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Phosphorylation</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gene Expression Regulation, Developmental</term>
<term>Phosphorylation</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Animals, Genetically Modified</term>
<term>Cells, Cultured</term>
<term>Genotype</term>
<term>In Situ Hybridization</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animal génétiquement modifié</term>
<term>Animaux</term>
<term>Cellules cultivées</term>
<term>Génotype</term>
<term>Hybridation in situ</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Vascular endothelial growth factor C (Vegfc) activates its receptor, Flt4, to induce lymphatic development. However, the signals that act downstream of Flt4 in this context in vivo remain unclear. To understand Flt4 signaling better, we generated zebrafish bearing a deletion in the Flt4 cytoplasmic domain that eliminates tyrosines Y1226 and 1227. Embryos bearing this deletion failed to initiate sprouting or differentiation of trunk lymphatic vessels and did not form a thoracic duct. Deletion of Y1226/7 prevented ERK phosphorylation in lymphatic progenitors, and ERK inhibition blocked trunk lymphatic sprouting and differentiation. Conversely, endothelial autonomous ERK activation rescued lymphatic sprouting and differentiation in flt4 mutants. Interestingly, embryos bearing the Y1226/7 deletion formed a functional facial lymphatic network enabling them to develop normally to adulthood. By contrast, flt4 null larvae displayed hypoplastic facial lymphatics and severe lymphedema. Thus, facial lymphatic vessels appear to be the first functional lymphatic network in the zebrafish, whereas the thoracic duct is initially dispensable for lymphatic function. Moreover, distinct signaling pathways downstream of Flt4 govern lymphatic morphogenesis and differentiation in different anatomical locations.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Shin, Masahiro" sort="Shin, Masahiro" uniqKey="Shin M" first="Masahiro" last="Shin">Masahiro Shin</name>
</region>
<name sortKey="Beane, Timothy J" sort="Beane, Timothy J" uniqKey="Beane T" first="Timothy J" last="Beane">Timothy J. Beane</name>
<name sortKey="Kok, Fatma O" sort="Kok, Fatma O" uniqKey="Kok F" first="Fatma O" last="Kok">Fatma O. Kok</name>
<name sortKey="Lawson, Nathan D" sort="Lawson, Nathan D" uniqKey="Lawson N" first="Nathan D" last="Lawson">Nathan D. Lawson</name>
<name sortKey="Male, Ira" sort="Male, Ira" uniqKey="Male I" first="Ira" last="Male">Ira Male</name>
<name sortKey="Villefranc, Jacques A" sort="Villefranc, Jacques A" uniqKey="Villefranc J" first="Jacques A" last="Villefranc">Jacques A. Villefranc</name>
<name sortKey="Zhu, Lihua J" sort="Zhu, Lihua J" uniqKey="Zhu L" first="Lihua J" last="Zhu">Lihua J. Zhu</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000936 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000936 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:27621059
   |texte=   Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:27621059" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors.

Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.